Tadalafil, more commonly known and sold under the brand name, Cialis, was originally developed by biotechnology company, ICOS, and developed and marketed globally by Lilly ICOS, LLC, a joint collaboration of the ICOS Corporation and Eli Lilly and Company. You can save on brand name and generic Cialis by shopping online at a Canadian pharmacy.

The drug is used primarily to treat male sexual function problems, specifically erectile dysfunction or impotence, by increasing blood flow to the penis. In combination with sexual stimulation, Cialis helps men to get, and maintain an erection.

Cialis, and generic Cialis, is also used to treat symptoms of benign prostatic hyperplasia- BPH (enlarged prostate) such as difficulty in the flow of urine, weak stream and the need to urinate frequently or urgently. The drug accomplishes this by relaxing the smooth muscles found in both the prostate and bladder. Cialis is also sold under the moniker, Adcirca, for treatment of pulmonary arterial hypertension (high blood pressure), and in India under the name Tadacip.

Cialis is a phosphodiesterase type 5 inhibitor (PDE5) used in its ED focus to block the degradation of a specific enzyme, cGMP, on the muscle cells of the corpus cavernosum of the penis. The main difference between Cialis (or generic Cialis) and its main competitors, Viagra, and Levitra, is a distinctly longer half-life of an approximate 17.5 hours, compared to 4-5 hours. This perceived advantage has given Cialis the affectionate nickname as the “Weekend Pill.” PDE5 is also found in the arterial wall of the lungs, hence its use in pulmonary hypertension as well.