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  • Categories / Allergy Relief / Phenergan ®

Phenergan (Promethazine)

  • Phenergan
Active Ingredient: Promethazine
Phenergan is used for relieving allergy symptoms, including hives or runny nose. It is used to prevent and control nausea and vomiting during and after surgery. It is also used as a sedative or sleep aid.
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Phenergan ®

Phenergan (promethazine) belongs to a group of drugs called phenothiazines. It works by changing the actions of chemicals in your brain. Promethazine also acts as an antihistamine. It blocks the effects of the naturally occurring chemical histamine in your body.

How does Phenergan work?

Phenergan contains promethazine, an antihistamine having a spot with phenothiazine social event of prescriptions that also has antiemetic (hinders infection) and opiate properties. Histamine is a compound released from post cells, (cells related to hypersensitivities) as a noteworthy part of the body's obstruction segment in the midst of an ominously helpless reaction. Histamine binds to H1 receptors in little veins making them spill, allowing white platelets and blood proteins into the tissues.

These entering cells produce blazing manufactured inventions (prostaglandins and leukotrienes) that reason tissue swelling and irritation, which are signs of an ominously defenseless reaction. Promethazine in Phenergan is H1 receptor opponent and works by definitive to histamine receptors and blocking the action of histamine without impeding its emanation. This movement squares histamine-interceded horribly helpless reactions, quieting signs in the upper respiratory tract like nasal stop up, runny vexatious nose and wheezing, and in the skin like redness, swelling, and shivering. Promethazine in Phenergan furthermore follows up on the central tactile framework (CNS).

Some cerebrum neurons (nerve cells) produce histamine and the action of histamine in the brain is locked in with weight and apprehension reactions. Blocking these mind histamine receptors is accepted to be responsible for causing sedation. A comparable CNS instrument is furthermore accountable for the counter-emetic effect of Phenergan tablets. Development issue is achieved by conflicting information being gotten by the cerebrum from the eyes and the vestibular structure in the inside ear; messages sent by the ear propose development, while the messages sent by the eye suggest that the body is still. The conflicting information got into the cerebrum and quickens the heaving focal point of the brain to prompt the regurgitating reflex. Promethazine in Phenergan tablets binds to histamine receptors on cells of the vestibular mechanical get-together of the inside ear and is moreover thought to bind to histamine receptors on nerve cells in the cerebrum to deter the transmission of nerve main thrusts from the internal ear to the spewing center in the psyche, which subsequently keeps transmission of nerve signals from the cerebrum to receptors in the stomach, so the hurling reflex is blocked.

What is Phenergan used for?

Phenergan Tablets are used to treat the accompanying conditions:

For momentary use: to treat grown-ups with trouble resting (a sleeping disorder)

To treat unfavorably susceptible conditions, for example, roughage fever or rashes

(like bother rash or hives)

To treat or stop you from feeling debilitated (queasiness) or being wiped out

(spewing, for example, travel infection)

For transient use: as a narcotic for kids matured 5 years or more.

How to use Phenergan?

Take this medication by mouth with or without sustenance as composed by your expert, generally, 2 to different occasions step by step. For development illness, the principal segment of promethazine should be taken 30 to an hour before beginning travel. For sensitivities, this remedy may be taken once step by step at rest time to refrain from being drained in the midst of the day. Exactly when used before the therapeutic technique, promethazine may be taken the earlier night or just before the approach and may be continued sometime later as facilitated.

If you are using the liquid sort of this medicine, circumspectly measure the part using a remarkable assessing device/spoon. Do whatever it takes not to use a family spoon since you may not get the correct segment.

The estimations rely upon your age, sickness, and response to treatment. In children, the estimations may moreover be established on weight. Do whatever it takes not to extend your segment or take this medication more consistently than facilitated.


Missed dose

If you miss a dose, take it as soon as you remember unless it's almost time for the next dose.

If that's the case, skip the missed dose and resume your regular dosing schedule.


Symptoms of an overdose may include:

Breathing problems




Loss of consciousness

Fast heartbeat

Loss of coordination

Twisting movements of the hands and feet


Tablets should be stored at room temperature, between 15 C to 25 C (68 F to 77 F). Suppositories should be stored at 2 C to 8 C (36 F to 46 F).

Before using this medication, tell your doctor or pharmacist your medical history, especially of: breathing problems (such as asthma, chronic obstructive pulmonary disease-COPD, sleep apnea), blood/immune system problems (such as bone marrow depression), high pressure in the eye (glaucoma), heart disease (such as irregular heartbeat), high blood pressure, liver disease, certain brain disorders (such as neuroleptic malignant syndrome, Reye's syndrome, seizures), stomach/intestine problems (such as blockage, ulcer), overactive thyroid (hyperthyroidism), difficulty urinating (for example, due to enlarged prostate).

This drug may make you dizzy or drowsy or cause blurred vision. Do not drive, use machinery, or do any activity that requires alertness or clear vision until you are sure you can perform such activities safely. Avoid alcoholic beverages.

Before having surgery, tell your doctor or dentist about all the products you use (including prescription drugs, nonprescription drugs, and herbal products).


·         Dry mouth,

·         Loss of appetite,

·         Nausea,

·         Vomiting,

·         Diarrhoea,

·         Constipation,

·         Sedation,

·         Restlessness,

·         Dizziness,

·         Fatigue,

·         Uncoordination,

·         Blurred vision.

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